Refinement GAPDH

Model TLS R Rfree

iso/rB 0 23.6 30.3

ani/rB 0 22.9 29.5

ani/rB 1 21.3 26.8

ani/rB 4 21.1 26.5

iso/20 0 30.0 35.7

ani/20 0 29.5 35.2

ani/20 1 25.1 29.4

ani/20 4 24.4 28.8

iso = isotropic scaling; ani = anisotropic scaling

rB = TLS refinement starting from refined Bs; 20 = TLS refinement starting from Bs fixed to 20 Å2