blastp BLASTP 2.2.26+ Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. pdb 46400 2CHL 328 BLOSUM62 10 11 1 F 1 46400 2CHL 328 1 gi|114794862|pdb|2IZR|A Chain A, Structure Of Casein Kinase Gamma 3 In Complex With Inhibitor >gi|114794863|pdb|2IZS|A Chain A, Structure Of Casein Kinase Gamma 3 In Complex With Inhibitor >gi|114794864|pdb|2IZT|A Chain A, Structure Of Casein Kinase Gamma 3 In Complex With Inhibitor >gi|114794865|pdb|2IZU|A Chain A, Structure Of Casein Kinase Gamma 3 In Complex With Inhibitor 2IZR_A 330 1 684.485 1765 0 1 328 3 330 0 0 328 328 0 328 GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ 2 gi|93279163|pdb|2CHL|A Chain A, Structure Of Casein Kinase 1 Gamma 3 2CHL_A 351 1 684.485 1765 0 1 328 24 351 0 0 328 328 0 328 GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ 3 gi|83754634|pdb|2C47|A Chain A, Structure Of Casein Kinase 1 Gamma 2 >gi|83754635|pdb|2C47|B Chain B, Structure Of Casein Kinase 1 Gamma 2 >gi|83754636|pdb|2C47|C Chain C, Structure Of Casein Kinase 1 Gamma 2 >gi|83754637|pdb|2C47|D Chain D, Structure Of Casein Kinase 1 Gamma 2 2C47_A 313 1 579.326 1492 0 5 306 2 304 0 0 275 288 1 303 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQD MGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPXGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTD +GPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP+KSRAPQLHLEYRFYKQL + +G+PQVYYFGP GKYNAMVLELLGPSLEDLFDLCDRTF+LKTVLMIAIQLI+RMEYVH+K+LIYRDVKPENFL+GRPG K Q IHIIDF LAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR G++FDYEYDW GK LPTP+G V D 4 gi|110591041|pdb|2CMW|A Chain A, Structure Of Human Casein Kinase 1 Gamma-1 In Complex With 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9- Isopropylpurine (Casp Target) 2CMW_A 310 1 566.614 1459 0 8 311 1 306 0 0 272 287 2 306 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGS-GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSS SMRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPXGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASA + RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP+KSRAPQLHLEYRFYKQLGS G+G+PQVYYFGP GKYNAMVLELLGPSLEDLFDLCDRTF+LKTVLMIAIQL+SRMEYVHSKNLIYRDVKPENFLIGR GNK + VIHIIDF LAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR TPIE LCENFP EMATYLRYVRRLDFFEKPDY+YLR LFTDLF++KGY FDY YDW+G+ +PTPVG+V D S+ 5 gi|371927698|pdb|3UYS|A Chain A, Crystal Structure Of Apo Human Ck1d >gi|371927699|pdb|3UYS|B Chain B, Crystal Structure Of Apo Human Ck1d >gi|371927700|pdb|3UYS|C Chain C, Crystal Structure Of Apo Human Ck1d >gi|371927701|pdb|3UYS|D Chain D, Crystal Structure Of Apo Human Ck1d >gi|371927702|pdb|3UYT|A Chain A, Crystal Structure Of Ck1d With Pf670462 From P1 Crystal Form >gi|371927703|pdb|3UYT|B Chain B, Crystal Structure Of Ck1d With Pf670462 From P1 Crystal Form >gi|371927704|pdb|3UYT|C Chain C, Crystal Structure Of Ck1d With Pf670462 From P1 Crystal Form >gi|371927705|pdb|3UYT|D Chain D, Crystal Structure Of Ck1d With Pf670462 From P1 Crystal Form >gi|371927706|pdb|3UZP|A Chain A, Crystal Structure Of Ck1d With Pf670462 From P21 Crystal Form >gi|371927707|pdb|3UZP|B Chain B, Crystal Structure Of Ck1d With Pf670462 From P21 Crystal Form 3UYS_A 296 1 360.533 924 3.66209e-125 3 291 5 292 0 0 172 225 3 290 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW L VG +R+G+KIG G+FG++ LG ++ E VAIKLE +K++ PQLH+E + YK + G GIP + + G G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSKN I+RDVKP+NFL+G K +++IIDF LAK+Y D T +HIPYRE+K+LTGTARY SINTHLG EQSRRDDLE+LG++ MYF GSLPWQGLKA T +++Y++I + K +TPIEVLC+ +P E ATYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW 6 gi|1311054|pdb|1CKJ|A Chain A, Casein Kinase I Delta Truncation Mutant Containing Residues 1-317 Complex With Bound Tungstate >gi|1311055|pdb|1CKJ|B Chain B, Casein Kinase I Delta Truncation Mutant Containing Residues 1-317 Complex With Bound Tungstate >gi|1311056|pdb|1CKI|A Chain A, Recombinant Casein Kinase I Delta Truncation Mutant Containing Residues 1-317 >gi|1311057|pdb|1CKI|B Chain B, Recombinant Casein Kinase I Delta Truncation Mutant Containing Residues 1-317 1CKJ_A 317 1 360.147 923 1.08251e-124 3 291 3 290 0 0 172 225 3 290 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDW L VG +R+G+KIG G+FG++ LG ++ E VAIKLE +K++ PQLH+E + YK + G GIP + + G G YN MV+ELLGPSLEDLF+ C R FSLKTVL++A Q+ISR+EY+HSKN I+RDVKP+NFL+G K +++IIDF LAK+Y D T +HIPYRE+K+LTGTARY SINTHLG EQSRRDDLE+LG++ MYF GSLPWQGLKA T +++Y++I + K +TPIEVLC+ +P E ATYL + R L F +KPDY YLR+LF +LF R+G+ +DY +DW 7 gi|15988262|pdb|1EH4|A Chain A, Binary Complex Of Casein Kinase-1 From S. Pombe With An Atp Competitive Inhibitor, Ic261 >gi|15988263|pdb|1EH4|B Chain B, Binary Complex Of Casein Kinase-1 From S. Pombe With An Atp Competitive Inhibitor, Ic261 >gi|157830703|pdb|1CSN|A Chain A, Binary Complex Of Casein Kinase-1 With Mgatp 1EH4_A 298 1 357.066 915 9.33042e-124 4 291 7 295 0 0 168 218 1 289 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW VVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLNTTEDENFDW +VG +++VG++IG G+FG + G NL N+ VAIK EP +S APQL EYR YK L GIP VYYFG G +N +V++LLGPSLEDL DLC R FS+KTV M A Q+++R++ +H K+L+YRD+KP+NFLIGRP +K +I+++DF + K Y DP TK+HIPYRE K+L+GTARYMSINTHLG+EQSRRDDLEALGH+FMYFLRGSLPWQGLKA T K++Y++IG+ K++TP+ LC FP E Y+ Y R L F PDYDYL+ LF+ + +R D +DW 8 gi|157834770|pdb|2CSN|A Chain A, Binary Complex Of Casein Kinase-1 With Cki7 2CSN_A 297 1 356.681 914 9.73588e-124 4 291 6 294 0 0 168 218 1 289 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW VVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLNTTEDENFDW +VG +++VG++IG G+FG + G NL N+ VAIK EP +S APQL EYR YK L GIP VYYFG G +N +V++LLGPSLEDL DLC R FS+KTV M A Q+++R++ +H K+L+YRD+KP+NFLIGRP +K +I+++DF + K Y DP TK+HIPYRE K+L+GTARYMSINTHLG+EQSRRDDLEALGH+FMYFLRGSLPWQGLKA T K++Y++IG+ K++TP+ LC FP E Y+ Y R L F PDYDYL+ LF+ + +R D +DW 9 gi|307568451|pdb|3OP5|A Chain A, Human Vaccinia-Related Kinase 1 >gi|307568452|pdb|3OP5|B Chain B, Human Vaccinia-Related Kinase 1 >gi|307568453|pdb|3OP5|C Chain C, Human Vaccinia-Related Kinase 1 >gi|307568454|pdb|3OP5|D Chain D, Human Vaccinia-Related Kinase 1 3OP5_A 364 1 110.923 276 1.06485e-27 4 274 32 324 0 0 85 146 44 304 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA------IKLEPMKSRAPQLHLEYRFYKQLGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK---RATPIEVLCENFP------EMATYLRYVRRLDFFEKPDYDYLRKLF MAAAAWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYCPEGVHKAYAADPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE----DNLKDP-KYVRDSKIRYRENIASLMDKCFPAANAPGEIAKYMETVKLLDYTEKPLYENLRDIL M ++VG IG G FG + L ++ ++E V +K+EP S L E +FY++ + G+P+ + G K Y M+++ G L+ +++ + FS KTVL ++++++ +EY+H ++ D+K N L+ K ++++D+ LA Y K + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D LK+ + + D+K R ++ + FP E+A Y+ V+ LD+ EKP Y+ LR + 10 gi|332138054|pdb|2LAV|A Chain A, Nmr Solution Structure Of Human Vaccinia-Related Kinase 1 2LAV_A 361 1 109.383 272 3.86235e-27 4 274 32 324 0 0 85 146 44 304 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA------IKLEPMKSRAPQLHLEYRFYKQLGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK---RATPIEVLCENFP------EMATYLRYVRRLDFFEKPDYDYLRKLF MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE----DNLKDP-KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL M ++VG IG G FG + L ++ ++E V +K+EP S L E +FY++ + G+P+ + G K Y M+++ G L+ +++ + FS KTVL ++++++ +EY+H ++ D+K N L+ K ++++D+ LA Y K + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D LK+ + + D+K R ++ + FP E+A Y+ V+ LD+ EKP Y+ LR + 11 gi|323462751|pdb|2KTY|A Chain A, Solution Structure Of Human Vaccinia Related Kinase-1 >gi|323714303|pdb|2KUL|A Chain A, Solution Structure Of Human Vaccinia Related Kinase 1(Vrk1) 2KTY_A 368 1 109.383 272 4.26816e-27 4 274 32 324 0 0 85 146 44 304 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA------IKLEPMKSRAPQLHLEYRFYKQLGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK---RATPIEVLCENFP------EMATYLRYVRRLDFFEKPDYDYLRKLF MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE----DNLKDP-KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL M ++VG IG G FG + L ++ ++E V +K+EP S L E +FY++ + G+P+ + G K Y M+++ G L+ +++ + FS KTVL ++++++ +EY+H ++ D+K N L+ K ++++D+ LA Y K + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D LK+ + + D+K R ++ + FP E+A Y+ V+ LD+ EKP Y+ LR + 12 gi|159795559|pdb|2V62|A Chain A, Structure Of Vaccinia-Related Kinase 2 >gi|159795560|pdb|2V62|B Chain B, Structure Of Vaccinia-Related Kinase 2 2V62_A 345 1 99.7525 247 8.88443e-24 4 275 34 324 0 0 88 132 43 303 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHLEYRFYKQLGSGD--------------GIPQVYYFGPCG----KYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFT MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE-YQENGP-LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY---KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EIAQFLVCAHSLAYDEKPNYQALKKILN M G + +GKKIG G FG + L E A +K+E + P L E +FY+++ D GIP Y G Y MV+E LG L+ + + TF TVL + I+++ +EY+H ++ D+K N L+G K +++ D+ L+ Y K K GT + S++ H G SRR D+E LG+ + +L G LPW Q K + L E Q + K A C E+A +L L + EKP+Y L+K+ 13 gi|152149135|pdb|2JII|A Chain A, Structure Of Vaccinia Related Kinase 3 >gi|152149136|pdb|2JII|B Chain B, Structure Of Vaccinia Related Kinase 3 2JII_A 352 1 80.8777 198 4.13263e-17 64 271 118 328 0 0 62 102 13 216 GIPQVYYFGP-CGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PEMATYLRYVRRLDFFEKPDYDYLR AIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD-PEDQSQ--VTLAGYGFAFRYC--PSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR IP FG KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN + P +++Q + + + A Y + KH+ Y E G ++S++ H G SRR DL++LG+ + +L G LPW +T QK + P C ++ + YL+ V L + EKP Y LR 14 gi|215794787|pdb|3F61|A Chain A, Crystal Structure Of M. Tuberculosis Pknb Leu33aspVAL222ASP DOUBLE MUTANT IN COMPLEX WITH ADP 3F61_A 311 1 71.2478 173 5.56487e-14 9 230 14 232 0 0 57 101 21 231 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMI-----SATNAVKVMDFGIARAIADSGNS----VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPDSVA--YQHV + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N +I + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G D++ YQ + 15 gi|215794788|pdb|3F69|A Chain A, Crystal Structure Of The Mycobacterium Tuberculosis Pknb Mutant Kinase Domain In Complex With Kt5720 >gi|215794789|pdb|3F69|B Chain B, Crystal Structure Of The Mycobacterium Tuberculosis Pknb Mutant Kinase Domain In Complex With Kt5720 3F69_A 311 1 70.4774 171 9.62833e-14 9 217 14 221 0 0 55 95 19 218 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANILI-----SATNAVKVVDFGIARAIADSGNS----VXQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N LI + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G 16 gi|329666168|pdb|3PWY|A Chain A, Crystal Structure Of An Extender (Spd28345)-Modified Human Pdk1 Complex 2 3PWY_A 311 1 70.0922 170 1.60266e-13 8 217 33 236 0 0 60 101 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGCLLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANSFVGTAQYVSPELLTEKSASKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ S GTA+Y+S K S+ DL ALG + + G P++ 17 gi|315113736|pdb|3ORM|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain D76a Mutant 3ORM_A 311 1 69.3218 168 2.44891e-13 9 217 14 221 0 0 54 95 19 218 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG YELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYATGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMI-----SATNAVKVMDFGIARAIADSGNS----VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N +I + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G 18 gi|315113730|pdb|3ORI|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 1) >gi|315113731|pdb|3ORI|B Chain B, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 1) >gi|315113732|pdb|3ORI|C Chain C, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 1) >gi|315113733|pdb|3ORI|D Chain D, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 1) >gi|315113734|pdb|3ORK|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 2) >gi|315113735|pdb|3ORL|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 3) >gi|315113737|pdb|3ORO|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 4) >gi|315113738|pdb|3ORP|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 5) >gi|315113739|pdb|3ORT|A Chain A, Mycobacterium Tuberculosis Pknb Kinase Domain L33d Mutant (Crystal Form 6) 3ORI_A 311 1 68.9366 167 3.67013e-13 9 217 14 221 0 0 54 95 19 218 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMI-----SATNAVKVMDFGIARAIADSGNS----VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N +I + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G 19 gi|28374107|pdb|1O6Y|A Chain A, Catalytic Domain Of Pknb Kinase From Mycobacterium Tuberculosis >gi|112490636|pdb|2FUM|A Chain A, Catalytic Domain Of Protein Kinase Pknb From Mycobacterium Tuberculosis In Complex With Mitoxantrone >gi|112490637|pdb|2FUM|B Chain B, Catalytic Domain Of Protein Kinase Pknb From Mycobacterium Tuberculosis In Complex With Mitoxantrone >gi|112490638|pdb|2FUM|C Chain C, Catalytic Domain Of Protein Kinase Pknb From Mycobacterium Tuberculosis In Complex With Mitoxantrone >gi|112490639|pdb|2FUM|D Chain D, Catalytic Domain Of Protein Kinase Pknb From Mycobacterium Tuberculosis In Complex With Mitoxantrone 1O6Y_A 299 1 68.5514 166 4.25437e-13 9 217 31 238 0 0 54 95 19 218 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG YELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMI-----SATNAVKVMDFGIARAIADSGNS----VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N +I + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G 20 gi|28948659|pdb|1MRU|A Chain A, Intracellular SerTHR PROTEIN KINASE DOMAIN OF Mycobacterium Tuberculosis Pknb. >gi|28948660|pdb|1MRU|B Chain B, Intracellular SerTHR PROTEIN KINASE DOMAIN OF Mycobacterium Tuberculosis Pknb. 1MRU_A 311 1 68.5514 166 4.59887e-13 9 217 14 221 0 0 54 95 19 218 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSG---DGIPQVYYFG----PCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG YELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVH-TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMI-----SATNAVKVMDFGIARAIADSGNS----VTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG + +G+ +G G E+ L ++L + VA+K L +R P +L +R Q + I VY G P G +V+E + G +L D+ + + K + + + + H +I+RDVKP N +I + ++DF +A+ D + ++ GTA+Y+S G R D+ +LG + L G P+ G 21 gi|47169418|pdb|1V0B|A Chain A, Crystal Structure Of The T198a Mutant Of Pfpk5 >gi|47169419|pdb|1V0B|B Chain B, Crystal Structure Of The T198a Mutant Of Pfpk5 1V0B_A 288 1 68.1662 165 4.93391e-13 13 252 8 234 0 0 65 112 23 245 KKIGCGNFGELRLGKNLYTNEYV--AIKLEPMKSRAPQLHL-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRATPIEVLCENFPEMATY EKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSN-IVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGE-----LKIADFGLARAF-------GIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILG-----TPNSKNWPNVTELPKY +KIG G +G + +N Y + I+LE P + E K+L + I ++Y K +V E L L+ L D+C+ T +QL++ + Y H + +++RD+KP+N LI R G + I DF LA+ + IP R++ T Y + + +G K+ S D+ ++G +F + G+ + G+ +AD L ++ +G TP N E+ Y 22 gi|48425852|pdb|1V0O|A Chain A, Structure Of P. Falciparum Pfpk5-Indirubin-5-Sulphonate Ligand Complex >gi|48425853|pdb|1V0O|B Chain B, Structure Of P. Falciparum Pfpk5-Indirubin-5-Sulphonate Ligand Complex 1V0O_A 288 1 68.1662 165 5.07601e-13 13 252 8 234 0 0 65 112 23 245 KKIGCGNFGELRLGKNLYTNEYV--AIKLEPMKSRAPQLHL-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRATPIEVLCENFPEMATY EKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSN-IVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGE-----LKIADFGLARAF-------GIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILG-----TPNSKNWPNVTELPKY +KIG G +G + +N Y + I+LE P + E K+L + I ++Y K +V E L L+ L D+C+ T +QL++ + Y H + +++RD+KP+N LI R G + I DF LA+ + IP R++ T Y + + +G K+ S D+ ++G +F + G+ + G+ +AD L ++ +G TP N E+ Y 23 gi|42543186|pdb|1OB3|A Chain A, Structure Of P. Falciparum Pfpk5 >gi|42543187|pdb|1OB3|B Chain B, Structure Of P. Falciparum Pfpk5 >gi|49259436|pdb|1V0P|A Chain A, Structure Of P. Falciparum Pfpk5-Purvalanol B Ligand Complex >gi|49259437|pdb|1V0P|B Chain B, Structure Of P. Falciparum Pfpk5-Purvalanol B Ligand Complex 1OB3_A 288 1 67.781 164 7.06776e-13 13 252 8 234 0 0 65 112 23 245 KKIGCGNFGELRLGKNLYTNEYV--AIKLEPMKSRAPQLHL-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRATPIEVLCENFPEMATY EKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSN-IVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGE-----LKIADFGLARAF-------GIPVRKYTHEIVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILG-----TPNSKNWPNVTELPKY +KIG G +G + +N Y + I+LE P + E K+L + I ++Y K +V E L L+ L D+C+ T +QL++ + Y H + +++RD+KP+N LI R G + I DF LA+ + IP R++ T Y + + +G K+ S D+ ++G +F + G+ + G+ +AD L ++ +G TP N E+ Y 24 gi|198443074|pdb|2R7B|A Chain A, Crystal Structure Of The Phosphoinositide-Dependent Kinase- 1 (Pdk-1)catalytic Domain Bound To A Dibenzonaphthyridine Inhibitor >gi|288563011|pdb|3ION|A Chain A, Pdk1 In Complex With Compound 8h 2R7B_A 312 1 67.781 164 8.29143e-13 8 217 34 237 0 0 59 100 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ S GTA+Y+S K + DL ALG + + G P++ 25 gi|312597396|pdb|3NAX|A Chain A, Pdk1 In Complex With Inhibitor Mp7 3NAX_A 311 1 67.781 164 9.47311e-13 8 217 30 233 0 0 59 100 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ S GTA+Y+S K + DL ALG + + G P++ 26 gi|61680895|pdb|2BIY|A Chain A, Structure Of Pdk1-S241a Mutant Kinase Domain 2BIY_A 310 1 67.0106 162 1.61906e-12 8 217 31 234 0 0 58 100 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANAFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ + GTA+Y+S K + DL ALG + + G P++ 27 gi|333944299|pdb|3NUS|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) With Fragment8 >gi|333944300|pdb|3NUU|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) With Fragment11 >gi|333944301|pdb|3NUY|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) With Fragment17 3NUS_A 286 1 66.2402 160 2.30155e-12 8 217 9 212 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 28 gi|47169288|pdb|1UU9|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Bim-3 1UU9_A 286 1 66.2402 160 2.32334e-12 8 217 10 213 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 29 gi|34811348|pdb|1H1W|A Chain A, High Resolution Crystal Structure Of The Human Pdk1 Catalytic Domain >gi|47169307|pdb|1UVR|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Bim-8 1H1W_A 289 1 66.2402 160 2.36254e-12 8 217 11 214 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 30 gi|66361318|pdb|1Z5M|A Chain A, Crystal Structure Of N1-[3-[[5-Bromo-2-[[3-[(1- Pyrrolidinylcarbonyl)amino]phenyl]amino]-4- Pyrimidinyl]amino]propyl]-2,2-Dimethylpropanediamide Complexed With Human Pdk1 >gi|149243092|pdb|2PE0|A Chain A, Crystal Structure Of Human Phosphoinositide-Dependent Protein Kinase 1 (Pdk1) 5-Hydroxy-3-[1-(1h-Pyrrol-2-Yl)- Eth-(Z)-Ylidene]-1,3-Dihydro-Indol-2-One Complex >gi|149243093|pdb|2PE1|A Chain A, Crystal Structure Of Human Phosphoinositide-Dependent Protein Kinase 1 (Pdk1) {2-Oxo-3-[1-(1h-Pyrrol-2-Yl)-Eth- (Z)-Ylidene]-2,3-Dihydro-1h-Indol-5-Yl}-Urea {bx-517} Complex >gi|150261375|pdb|2PE2|A Chain A, Crystal Structure Of Human Phosphoinositide-Dependent Protein Kinase 1 (Pdk1) 3-{5-[2-Oxo-5-Ureido-1,2-Dihydro-Indol-(3z)-Ylidenemethyl]-1h- Pyrrol-3-Yl}-N-(2-Piperidin-1-Yl-Ethyl)-Benzamide Complex 1Z5M_A 286 1 66.2402 160 2.45847e-12 8 217 8 211 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 31 gi|157834827|pdb|2DWB|A Chain A, Aurora-A Kinase Complexed With Amppnp 2DWB_A 285 1 66.2402 160 2.83327e-12 8 238 14 231 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEXIEGRXHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 32 gi|340707715|pdb|3NUN|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) With Lead Compound 3NUN_A 292 1 65.855 159 3.12355e-12 8 217 15 218 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 33 gi|357380610|pdb|3RWP|A Chain A, Discovery Of A Novel, Potent And Selective Inhibitor Of 3- Phosphoinositide Dependent Kinase (Pdk1) 3RWP_A 311 1 66.2402 160 3.22674e-12 8 217 33 236 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 34 gi|47169285|pdb|1UU3|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Ly333531 >gi|47169286|pdb|1UU7|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Bim-2 >gi|47169287|pdb|1UU8|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Bim-1 >gi|51247135|pdb|1OKY|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Staurosporine >gi|51247136|pdb|1OKZ|A Chain A, Structure Of Human Pdk1 Kinase Domain In Complex With Ucn-01 1UU3_A 310 1 65.855 159 3.72053e-12 8 217 31 234 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 35 gi|301598403|pdb|2XCH|A Chain A, Crystal Structure Of Pdk1 In Complex With A Pyrazoloquinazoline Inhibitor 2XCH_A 309 1 65.855 159 3.76408e-12 8 217 31 234 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 36 gi|258588536|pdb|3HRC|A Chain A, Crystal Structure Of A Mutant Of Human Pdk1 Kinase Domain In Complex With Atp >gi|258588537|pdb|3HRF|A Chain A, Crystal Structure Of Human Pdk1 Kinase Domain In Complex With An Allosteric Activator Bound To The Pif-Pocket >gi|340708062|pdb|3RCJ|A Chain A, Rapid Preparation Of Triazolyl Substituted Nh-Heterocyclic Kinase Inhibitors Via One-Pot Sonogashira Coupling Tms-Deprotection Cuaac Sequence >gi|359546266|pdb|4A06|A Chain A, Human Pdk1 Kinase Domain In Complex With Allosteric Activator Ps114 Bound To The Pif-Pocket 3HRC_A 311 1 65.855 159 3.85298e-12 8 217 33 236 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 37 gi|354459580|pdb|3SC1|A Chain A, Novel Isoquinolone Pdk1 Inhibitors Discovered Through Fragment-Based Lead Discovery >gi|357380611|pdb|3RWQ|A Chain A, Discovery Of A Novel, Potent And Selective Inhibitor Of 3- Phosphoinositide Dependent Kinase (Pdk1) 3SC1_A 311 1 65.855 159 3.8891e-12 8 217 33 236 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 38 gi|288965489|pdb|3IOP|A Chain A, Pdk-1 In Complex With The Inhibitor Compound-8i >gi|325534037|pdb|3QCQ|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 6-(3- Amino-1h-Indazol-6-Yl)-N4-Ethyl-2,4-Pyrimidinediamine >gi|325534038|pdb|3QCS|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 6-[2- Amino-6-(4-Morpholinyl)-4-Pyrimidinyl]-1h-Indazol-3-Amine >gi|325534039|pdb|3QCX|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 6-{2- Amino-6-[(3r)-3-Methyl-4-Morpholinyl]-4-Pyrimidinyl}-1h-Indazol-3- Amine >gi|325534040|pdb|3QCY|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 4-[2- Amino-6-(3-Amino-1h-Indazol-6-Yl)-4-Pyrimidinyl]-N-Phenyl-2- Morpholinecarboxamide >gi|325534041|pdb|3QD0|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With (2r,5s)- 1-[2-Amino-6-(3-Amino-1h-Indazol-6-Yl)-4-Pyrimidinyl]-6-Methyl-N- Phenyl-3-Piperidinecarboxamide >gi|325534042|pdb|3QD3|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 1,1- Dimethylethyl {(3r,6s)-1-[2-Amino-6-(3-Amino-1h-Indazol-6-Yl)-4- Pyrimidinyl]-6-Methyl-3-Piperidinyl}carbamate >gi|325534043|pdb|3QD4|A Chain A, Phosphoinositide-Dependent Kinase-1 (Pdk1) Kinase Domain With 1,1- Dimethylethyl{(3r,5r)-1-[2-Amino-6-(3-Amino-1h-Indazol-6-Yl)-4- Pyrimidinyl]-5-Methyl-3-Piperidinyl}carbamate 3IOP_A 312 1 65.855 159 3.95268e-12 8 217 34 237 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 39 gi|312597397|pdb|3NAY|A Chain A, Pdk1 In Complex With Inhibitor Mp6 >gi|312597398|pdb|3NAY|B Chain B, Pdk1 In Complex With Inhibitor Mp6 3NAY_A 311 1 65.855 159 4.0748e-12 8 217 30 233 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 40 gi|326634412|pdb|3ORX|A Chain A, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634413|pdb|3ORX|B Chain B, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634414|pdb|3ORX|C Chain C, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634415|pdb|3ORX|D Chain D, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634416|pdb|3ORX|E Chain E, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634417|pdb|3ORX|F Chain F, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634418|pdb|3ORX|G Chain G, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634419|pdb|3ORX|H Chain H, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Inhibitor 1f8 >gi|326634420|pdb|3ORZ|A Chain A, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Activator 2a2 >gi|326634421|pdb|3ORZ|B Chain B, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Activator 2a2 >gi|326634422|pdb|3ORZ|C Chain C, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Activator 2a2 >gi|326634423|pdb|3ORZ|D Chain D, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Activator 2a2 >gi|326634429|pdb|3OTU|A Chain A, Pdk1 Mutant Bound To Allosteric Disulfide Fragment Activator Js30 3ORX_A 316 1 65.855 159 4.09857e-12 8 217 38 241 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 41 gi|119390407|pdb|2J50|A Chain A, Structure Of Aurora-2 In Complex With Pha-739358 >gi|119390408|pdb|2J50|B Chain B, Structure Of Aurora-2 In Complex With Pha-739358 2J50_A 280 1 65.4698 158 4.13976e-12 8 238 9 226 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 42 gi|303325164|pdb|3O50|A Chain A, Crystal Structure Of Benzamide 9 Bound To Auroraa >gi|303325165|pdb|3O50|B Chain B, Crystal Structure Of Benzamide 9 Bound To Auroraa >gi|303325166|pdb|3O51|A Chain A, Crystal Structure Of Anthranilamide 10 Bound To Auroraa 3O50_A 267 1 65.4698 158 4.17213e-12 8 238 8 225 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 43 gi|183448376|pdb|3COK|A Chain A, Crystal Structure Of Plk4 Kinase >gi|183448377|pdb|3COK|B Chain B, Crystal Structure Of Plk4 Kinase 3COK_A 278 1 65.4698 158 4.18132e-12 8 230 12 224 0 0 63 105 24 230 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSR-----APQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI DFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL-KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRY-LKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMN-----IKIADFGLA-------TQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFD---TDTVKNTLNKV +F+VG +G G+F + ++++T VAIK+ K+ ++ E + + QL I ++Y + Y +VLE+ + + L +R FS Q+I+ M Y+HS +++RD+ N L+ R N I I DF LA T+ +P+ +H +L GT Y+S D+ +LG MF L G P+ DT+K K+ 44 gi|256599740|pdb|3H9O|A Chain A, Phosphoinositide-Dependent Protein Kinase 1 (Pdk-1) In Complex With Compound 9 3H9O_A 311 1 65.855 159 4.19046e-12 8 217 33 236 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 45 gi|37926805|pdb|1MQ4|A Chain A, Crystal Structure Of Aurora-A Protein Kinase >gi|122920939|pdb|2NP8|A Chain A, Structural Basis For The Inhibition Of Aurora A Kinase By A Novel Class Of High Affinity Disubstituted Pyrimidine Inhibitors >gi|295789274|pdb|2X81|A Chain A, Structure Of Aurora A In Complex With Mln8054 >gi|301015974|pdb|3MYG|A Chain A, Aurora A Kinase Complexed With Sch 1473759 1MQ4_A 272 1 65.4698 158 4.22075e-12 8 238 13 230 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 46 gi|359546268|pdb|4A07|A Chain A, Human Pdk1 Kinase Domain In Complex With Allosteric Activator Ps171 Bound To The Pif-Pocket 4A07_A 311 1 65.855 159 4.22973e-12 8 217 33 236 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSAXKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 47 gi|329666193|pdb|3QC4|A Chain A, Pdk1 In Complex With Dfg-Out Inhibitor Xxx >gi|329666194|pdb|3QC4|B Chain B, Pdk1 In Complex With Dfg-Out Inhibitor Xxx 3QC4_A 314 1 65.855 159 4.23725e-12 8 217 36 239 0 0 58 99 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F + L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 48 gi|251836969|pdb|3H0Y|A Chain A, Aurora A In Complex With A Bisanilinopyrimidine >gi|251836970|pdb|3H0Z|A Chain A, Aurora A In Complex With A Bisanilinopyrimidine >gi|251836971|pdb|3H0Z|B Chain B, Aurora A In Complex With A Bisanilinopyrimidine >gi|251836972|pdb|3H0Z|C Chain C, Aurora A In Complex With A Bisanilinopyrimidine >gi|251836973|pdb|3H10|A Chain A, Aurora A Inhibitor Complex >gi|251836974|pdb|3H10|B Chain B, Aurora A Inhibitor Complex >gi|251836975|pdb|3H10|D Chain D, Aurora A Inhibitor Complex >gi|326634439|pdb|3P9J|A Chain A, Aurora A Kinase Domain With Phthalazinone Pyrazole Inhibitor 3H0Y_A 268 1 65.4698 158 4.29473e-12 8 238 9 226 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRAALCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 49 gi|222142983|pdb|2W1D|A Chain A, Structure Determination Of Aurora Kinase In Complex With Inhibitor >gi|222142984|pdb|2W1E|A Chain A, Structure Determination Of Aurora Kinase In Complex With Inhibitor >gi|222142985|pdb|2W1F|A Chain A, Structure Determination Of Aurora Kinase In Complex With Inhibitor 2W1D_A 275 1 65.4698 158 4.30273e-12 8 238 12 229 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 50 gi|307568097|pdb|2XNG|A Chain A, Structure Of Aurora-A Bound To A Selective Imidazopyrazine Inhibitor 2XNG_A 283 1 65.4698 158 4.49952e-12 8 238 12 229 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 51 gi|30749504|pdb|1MUO|A Chain A, Crystal Structure Of Aurora-2, An Oncogenic Serine- Threonine Kinase 1MUO_A 297 1 65.4698 158 4.55817e-12 8 238 26 243 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 52 gi|300193137|pdb|2X6D|A Chain A, Aurora-A Bound To An Inhibitor >gi|300193138|pdb|2X6E|A Chain A, Aurora-A Bound To An Inhibitor 2X6D_A 285 1 65.4698 158 5.03031e-12 8 238 14 231 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 53 gi|119390405|pdb|2J4Z|A Chain A, Structure Of Aurora-2 In Complex With Pha-680626 >gi|119390406|pdb|2J4Z|B Chain B, Structure Of Aurora-2 In Complex With Pha-680626 2J4Z_A 306 1 65.4698 158 5.10898e-12 8 238 35 252 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 54 gi|88192580|pdb|2C6D|A Chain A, Aurora A Kinase Activated Mutant (T287d) In Complex With Adpnp 2C6D_A 275 1 64.6994 156 6.51593e-12 8 238 9 226 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 55 gi|303325137|pdb|3NRM|A Chain A, Imidazo[1,2-A]pyrazine-Based Aurora Kinase Inhibitors 3NRM_A 283 1 65.0846 157 6.61671e-12 8 238 12 229 0 0 58 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRAALCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 56 gi|301598406|pdb|2XCK|A Chain A, Crystal Structure Of Pdk1 In Complex With A Pyrazoloquinazoline Inhibitor 2XCK_A 309 1 65.0846 157 6.90285e-12 8 217 31 234 0 0 58 98 32 223 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP-------------MKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DFKFGKILGEGSFSTTVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYT--------AEIVSALEYLHGKGIIHRDLKPENILLNEDMH-----IQITDFGTAK-VLSPESKQ----ARANXFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRA +F+ GK +G G+F L + L T+ AIK+ + R L++ F+ +L + YFG N +L+ + + + C R ++ +++S +EY+H K +I+RD+KPEN L+ + I I DF AK + PE+K+ GTA+Y+S K + DL ALG + + G P++ 57 gi|307776323|pdb|2XRU|A Chain A, Aurora-A T288e Complexed With Pha-828300 2XRU_A 280 1 64.6994 156 7.28295e-12 8 238 9 226 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTELCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 58 gi|258588281|pdb|3FDN|A Chain A, Structure-Based Drug Design Of Novel Aurora Kinase A Inhibitors: Structure Basis For Potency And Specificity >gi|308387802|pdb|3K5U|A Chain A, Identification, Sar Studies And X-Ray Cocrystal Analysis Of A Novel Furano-Pyrimidine Aurora Kinase A Inhibitor >gi|325533914|pdb|3M11|A Chain A, Crystal Structure Of Aurora A Kinase Complexed With Inhibitor 3FDN_A 279 1 64.6994 156 7.70976e-12 8 238 10 227 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 59 gi|255311880|pdb|3HA6|A Chain A, Crystal Structure Of Aurora A In Complex With Tpx2 And Compound 10 3HA6_A 268 1 64.6994 156 7.79015e-12 8 238 9 226 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRXXLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 60 gi|210061010|pdb|3E5A|A Chain A, Crystal Structure Of Aurora A In Complex With Vx-680 And Tpx2 3E5A_A 268 1 64.6994 156 8.01398e-12 8 238 9 226 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTXLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 61 gi|260099804|pdb|2WQE|A Chain A, Structure Of S155r Aurora-A Somatic Mutant 2WQE_A 262 1 64.3142 155 8.61561e-12 8 238 6 223 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQRKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 62 gi|222142982|pdb|2W1C|A Chain A, Structure Determination Of Aurora Kinase In Complex With Inhibitor >gi|222142986|pdb|2W1G|A Chain A, Structure Determination Of Aurora Kinase In Complex With Inhibitor 2W1C_A 275 1 64.3142 155 8.72601e-12 8 238 12 229 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRXXLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 63 gi|343197352|pdb|3R21|A Chain A, Design, Synthesis, And Biological Evaluation Of Pyrazolopyridine- Sulfonamides As Potent Multiple-Mitotic Kinase (Mmk) Inhibitors (Part I) >gi|343197353|pdb|3R22|A Chain A, Design, Synthesis, And Biological Evaluation Of Pyrazolopyridine- Sulfonamides As Potent Multiple-Mitotic Kinase (Mmk) Inhibitors (Part I) 3R21_A 271 1 64.3142 155 8.8118e-12 8 238 12 229 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 64 gi|290560471|pdb|3LAU|A Chain A, Crystal Structure Of Aurora2 Kinase In Complex With A Gsk3beta Inhibitor 3LAU_A 287 1 64.6994 156 9.07161e-12 8 238 9 226 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 65 gi|88192581|pdb|2C6E|A Chain A, Aurora A Kinase Activated Mutant (T287d) In Complex With A 5-Aminopyrimidinyl Quinazoline Inhibitor >gi|88192582|pdb|2C6E|B Chain B, Aurora A Kinase Activated Mutant (T287d) In Complex With A 5-Aminopyrimidinyl Quinazoline Inhibitor 2C6E_A 283 1 64.6994 156 9.27954e-12 8 238 14 231 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 66 gi|62739016|pdb|2BMC|A Chain A, Aurora-2 T287d T288d Complexed With Pha-680632 >gi|62739017|pdb|2BMC|B Chain B, Aurora-2 T287d T288d Complexed With Pha-680632 >gi|62739018|pdb|2BMC|C Chain C, Aurora-2 T287d T288d Complexed With Pha-680632 >gi|62739019|pdb|2BMC|D Chain D, Aurora-2 T287d T288d Complexed With Pha-680632 >gi|62739020|pdb|2BMC|E Chain E, Aurora-2 T287d T288d Complexed With Pha-680632 >gi|62739021|pdb|2BMC|F Chain F, Aurora-2 T287d T288d Complexed With Pha-680632 2BMC_A 306 1 64.6994 156 9.45676e-12 8 238 35 252 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 67 gi|38492658|pdb|1OL5|A Chain A, Structure Of Aurora-A 122-403, Phosphorylated On Thr287, Thr288 And Bound To Tpx2 1-43 >gi|38492661|pdb|1OL7|A Chain A, Structure Of Human Aurora-A 122-403 Phosphorylated On Thr287, Thr288 1OL5_A 282 1 64.3142 155 9.55234e-12 8 238 11 228 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRXXLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 68 gi|218766694|pdb|3EFW|A Chain A, Structure Of Auroraa With Pyridyl-Pyrimidine Urea Inhibitor >gi|218766695|pdb|3EFW|B Chain B, Structure Of Auroraa With Pyridyl-Pyrimidine Urea Inhibitor 3EFW_A 403 1 64.6994 156 1.34704e-11 8 231 132 342 0 0 57 103 27 231 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIG DFEIGRPLGKGKFGNVYLAREKQSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRIS +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I 69 gi|223673937|pdb|3COH|A Chain A, Crystal Structure Of Aurora-A In Complex With A Pentacyclic Inhibitor >gi|223673938|pdb|3COH|B Chain B, Crystal Structure Of Aurora-A In Complex With A Pentacyclic Inhibitor 3COH_A 268 1 63.5438 153 1.50768e-11 8 238 9 226 0 0 57 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKNSKFILALKVL-FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDSTRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKKVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRAALCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQDTYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T ++ Y++I + P 70 gi|307568096|pdb|2XNE|A Chain A, Structure Of Aurora-A Bound To An Imidazopyrazine Inhibitor 2XNE_A 272 1 63.5438 153 1.55052e-11 8 238 12 229 0 0 57 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIANFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I +F + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 71 gi|38492660|pdb|1OL6|A Chain A, Structure Of Unphosphorylated D274n Mutant Of Aurora-A 1OL6_A 282 1 63.5438 153 1.77437e-11 8 238 11 228 0 0 57 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIANFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I +F + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 72 gi|284793810|pdb|2WTW|A Chain A, Aurora-A Inhibitor Structure (2nd Crystal Form) 2WTW_A 285 1 63.1586 152 2.69474e-11 8 238 14 231 0 0 57 105 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + G ++L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 73 gi|23200128|pdb|1H4L|A Chain A, Structure And Regulation Of The Cdk5-P25(Nck5a) Complex >gi|23200129|pdb|1H4L|B Chain B, Structure And Regulation Of The Cdk5-P25(Nck5a) Complex 1H4L_A 292 1 62.3882 150 4.57732e-11 13 250 8 231 0 0 68 108 28 245 KKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKRATPIEVLCENFPEMA EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE-----LKLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAARPLFPGNDVDDQLKRIFRLLG-----TPTE---EQWPSMT +KIG G +G + KN T+E VA+K L+ P L E K+L + I +++ K +V E L+ FD C+ + V QL+ + + HS+N+++RD+KP+N LI R G + + DF LA+ + IP R + + T Y + G K S D+ + G +F + P + G D LK ++ +G TP E E +P M 74 gi|193885442|pdb|3DAJ|A Chain A, Crystal Structure Of Aurora A Complexed With An Inhibitor Discovered Through Site-Directed Dynamic Tethering 3DAJ_A 272 1 62.3882 150 4.8308e-11 8 238 13 230 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFDIGRPLGKGKFGNVYLARERQSKFILALKV-LFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--RFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGE-----LKIADFGWS---------VHAPSSRRDTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFE---AHTYQETYRRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A T +E Y++I + P 75 gi|197305067|pdb|3D14|A Chain A, Crystal Structure Of Mouse Aurora A (Asn186->gly, Lys240- >arg, Met302->leu) In Complex With 1-{5-[2-(Thieno[3,2- D]pyrimidin-4-Ylamino)-Ethyl]- Thiazol-2-Yl}-3-(3- Trifluoromethyl-Phenyl)-Urea >gi|229597715|pdb|3DJ5|A Chain A, Crystal Structure Of The Mouse Aurora-A Catalytic Domain (Asn186->gly, Lys240->arg, Met302->leu) In Complex With Compound 290. >gi|229597716|pdb|3DJ6|A Chain A, Crystal Structure Of The Mouse Aurora-A Catalytic Domain (Asn186->gly, Lys240->arg, Met302->leu) In Complex With Compound 823. >gi|229597717|pdb|3DJ7|A Chain A, Crystal Structure Of The Mouse Aurora-A Catalytic Domain (Asn186->gly, Lys240->arg, Met302->leu) In Complex With Compound 130. >gi|237640459|pdb|3D15|A Chain A, Crystal Structure Of Mouse Aurora A (Asn186->gly, Lys240- >arg, Met302->leu) In Complex With 1-(3-Chloro-Phenyl)-3- {5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)- Ethyl]-Thiazol-2- Yl}-Urea [sns-314] >gi|237640468|pdb|3D2I|A Chain A, Crystal Structure Of Mouse Aurora A (Asn186->gly, Lys240- >arg, Met302->leu) In Complex With 1-{5-[2-(1-Methyl-1h- Pyrazolo[4,3-D]pyrimidin-7-Ylamino)-Ethyl]-Thiazol-2-Yl}-3- (3-Trifluoromethyl-Phenyl)-Urea >gi|237640469|pdb|3D2K|A Chain A, Crystal Structure Of Mouse Aurora A (Asn186->gly, Lys240- >arg, Met302->leu) In Complex With [7-(2-{2-[3-(3-Chloro- Phenyl)-Ureido]-Thiazol-5-Yl}-Ethylamino)-Pyrazolo[4,3- D]pyrimidin-1-Yl]-Acetic Acid 3D14_A 272 1 62.003 149 5.40601e-11 8 238 13 230 0 0 58 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFDIGRPLGKGKFGNVYLARERQSKFILALKV-LFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--RFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGE-----LKIADFGWS---------VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFE---AHTYQETYRRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + LG +L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P +L GT Y+ G+ + DL +LG + FL G P++ A T +E Y++I + P 76 gi|284793806|pdb|2WTV|A Chain A, Aurora-A Inhibitor Structure >gi|284793807|pdb|2WTV|B Chain B, Aurora-A Inhibitor Structure >gi|284793808|pdb|2WTV|C Chain C, Aurora-A Inhibitor Structure >gi|284793809|pdb|2WTV|D Chain D, Aurora-A Inhibitor Structure 2WTV_A 285 1 62.003 149 5.79626e-11 8 238 14 231 0 0 57 104 27 238 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGI--PQV-----YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP DFEIGRPLGKGKFGNVYLAREKQSKFILALKV-LFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLSK--FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGE-----LKIADFGWS---------VHAPSSRRXXLXGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFP +F +G+ +G G FG + L + + +A+K+ K++ + +E++ +++ + P + Y+ Y + G ++L L F + +L + + Y HSK +I+RD+KPEN L+G G + I DF + H P L GT Y+ G+ + DL +LG + FL G P++ A+T +E Y++I + P 77 gi|188036196|pdb|2Z7Q|A Chain A, Crystal Structure Of The N-Terminal Kinase Domain Of Human Rsk-1 Bound To Amp-Pcp >gi|188036197|pdb|2Z7R|A Chain A, Crystal Structure Of The N-Terminal Kinase Domain Of Human Rsk1 Bound To Staurosporine >gi|188036198|pdb|2Z7S|A Chain A, Crystal Structure Of The N-Terminal Kinase Domain Of Human Rsk1 Bound To Purvalnol A 2Z7Q_A 321 1 61.6178 148 9.94841e-11 91 217 116 232 0 0 43 63 14 129 DLFDLCDR--TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGH-----IKLTDFGLSKEAIDHEKKAY-------SFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQG DLF + F+ + V +L ++++HS +IYRD+KPEN L+ G+ I + DF L+KE ID E K + S GT YM+ + S D + G + L GSLP+QG 78 gi|281307024|pdb|3G51|A Chain A, Structural Diversity Of The Active Conformation Of The N- Terminal Kinase Domain Of P90 Ribosomal S6 Kinase 2 3G51_A 325 1 61.6178 148 1.14521e-10 91 217 112 228 0 0 41 64 14 129 DLFDLCDR--TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG DLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH-----IKLTDFGLSKESIDHEKKAY-------SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQG DLF + F+ + V +L ++++HS +IYRD+KPEN L+ G+ I + DF L+KE ID E K + S GT YM+ + ++ D + G + L G+LP+QG 79 gi|56966251|pdb|1UNG|A Chain A, Structural Mechanism For The Inhibition Of Cdk5-P25 By Roscovitine, Aloisine And Indirubin. >gi|56966252|pdb|1UNG|B Chain B, Structural Mechanism For The Inhibition Of Cdk5-P25 By Roscovitine, Aloisine And Indirubin. >gi|56966255|pdb|1UNH|A Chain A, Structural Mechanism For The Inhibition Of Cdk5-P25 By Roscovitine, Aloisine And Indirubin. >gi|56966256|pdb|1UNH|B Chain B, Structural Mechanism For The Inhibition Of Cdk5-P25 By Roscovitine, Aloisine And Indirubin. >gi|56966259|pdb|1UNL|A Chain A, Structural Mechanism For The Inhibition Of Cd5-P25 From The Roscovitine, Aloisine And Indirubin. >gi|56966260|pdb|1UNL|B Chain B, Structural Mechanism For The Inhibition Of Cd5-P25 From The Roscovitine, Aloisine And Indirubin. >gi|320089835|pdb|3O0G|A Chain A, Crystal Structure Of Cdk5:p25 In Complex With An Atp Analogue >gi|320089837|pdb|3O0G|B Chain B, Crystal Structure Of Cdk5:p25 In Complex With An Atp Analogue 1UNG_A 292 1 60.077 144 3.37116e-10 13 250 8 231 0 0 67 107 28 245 KKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLP-WQGLKA-DTLKERYQKIGDTKRATPIEVLCENFPEMA EKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN-IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGE-----LKLANFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG-----TPTE---EQWPSMT +KIG G +G + KN T+E VA+K L+ P L E K+L + I +++ K +V E L+ FD C+ + V QL+ + + HS+N+++RD+KP+N LI R G + + +F LA+ + IP R + + T Y + G K S D+ + G +F P + G D LK ++ +G TP E E +P M 80 gi|270346335|pdb|2WQM|A Chain A, Structure Of Apo Human Nek7 >gi|270346336|pdb|2WQN|A Chain A, Structure Of Adp-Bound Human Nek7 2WQM_A 310 1 59.6918 143 5.24339e-10 8 221 33 242 0 0 66 95 28 226 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK------LEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDL------FDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKAD NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK-EIDLLKQLNHPNVIKYYASFIEDNELN-IVLELADAG--DLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATG-----VVKLGDLGLGRFFSSKTTAAH-------SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMN NFR+ KKIG G F E+ L VA+K L K+RA + E KQL + I F + N +VLEL DL F R +TV +QL S +E++HS+ +++RD+KP N I G V+ + D L + + T H SL GT YMS + + D+ +LG + P+ G K + 81 gi|109157913|pdb|2GNG|A Chain A, Protein Kinase A Fivefold Mutant Model Of Rho-Kinase >gi|109157915|pdb|2GNH|A Chain A, Pka Five Fold Mutant Model Of Rho-Kinase With H1152p >gi|109157917|pdb|2GNI|A Chain A, Pka Fivefold Mutant Model Of Rho-Kinase With Inhibitor Fasudil (Ha1077) 2GNG_A 350 1 59.6918 143 5.79032e-10 13 320 47 334 0 0 80 133 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTIGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYMPGG--DMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIKVADFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K IG G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + D+F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 82 gi|109157911|pdb|2GNF|A Chain A, Protein Kinase A Fivefold Mutant Model Of Rho-Kinase With Y- 27632 2GNF_A 350 1 59.6918 143 5.95088e-10 13 320 47 334 0 0 80 133 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTIGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYMPGG--DMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIKVADFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K IG G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + D+F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 83 gi|90108640|pdb|1ZMU|A Chain A, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: Wild Type >gi|90108641|pdb|1ZMU|B Chain B, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: Wild Type 1ZMU_A 327 1 59.3066 142 6.55548e-10 8 246 15 243 0 0 63 111 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFG--------NKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+K+ + S +L E R K L + I +++ K +V+E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 84 gi|197304948|pdb|2R0I|A Chain A, Crystal Structure Of A Kinase Mark2PAR-1 Mutant >gi|197304949|pdb|2R0I|B Chain B, Crystal Structure Of A Kinase Mark2PAR-1 Mutant 2R0I_A 327 1 59.3066 142 7.05361e-10 8 246 15 243 0 0 64 112 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFGN--------KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+K+ + S +L E R K L + I +++ K +V+E S ++FD +K A Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 85 gi|158430348|pdb|2QNJ|A Chain A, Kinase And Ubiquitin-Associated Domains Of Mark3PAR-1 >gi|158430349|pdb|2QNJ|B Chain B, Kinase And Ubiquitin-Associated Domains Of Mark3PAR-1 2QNJ_A 328 1 59.3066 142 7.08586e-10 8 258 13 253 0 0 65 114 24 258 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP----QLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRR NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN-IVKLFEVIETEKTLYLIMEY--ASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-----IKIADFGFSNEF--------TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENLLKRFLVLNPIKR N+R+ K IG GNF +++L +++ T VAIK+ P +L E R K L + I +++ K +++E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN + L ++R 86 gi|270346595|pdb|3IEC|A Chain A, Helicobacter Pylori Caga Inhibits Par1MARK FAMILY KINASES By Mimicking Host Substrates >gi|270346596|pdb|3IEC|B Chain B, Helicobacter Pylori Caga Inhibits Par1MARK FAMILY KINASES By Mimicking Host Substrates >gi|270346597|pdb|3IEC|C Chain C, Helicobacter Pylori Caga Inhibits Par1MARK FAMILY KINASES By Mimicking Host Substrates >gi|270346598|pdb|3IEC|D Chain D, Helicobacter Pylori Caga Inhibits Par1MARK FAMILY KINASES By Mimicking Host Substrates 3IEC_A 319 1 58.9214 141 8.08173e-10 8 246 8 236 0 0 63 111 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGWMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFG--------NKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+K+ + S +L E R K L + I +++ K +V+E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 87 gi|112491250|pdb|2HAK|A Chain A, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491251|pdb|2HAK|B Chain B, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491252|pdb|2HAK|C Chain C, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491253|pdb|2HAK|D Chain D, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491254|pdb|2HAK|E Chain E, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491255|pdb|2HAK|F Chain F, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491256|pdb|2HAK|G Chain G, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 >gi|112491257|pdb|2HAK|H Chain H, Catalytic And Ubiqutin-Associated Domains Of Mark1PAR-1 2HAK_A 328 1 58.9214 141 9.32417e-10 8 226 16 225 0 0 59 102 23 226 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP----QLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKER NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-----IKIADFGFSNEF--------TVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER N+R+ K IG GNF +++L +++ T VA+K+ P +L E R K L + I +++ K +V+E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER 88 gi|99032135|pdb|2F2U|A Chain A, Crystal Structure Of The Rho-Kinase Kinase Domain >gi|99032136|pdb|2F2U|B Chain B, Crystal Structure Of The Rho-Kinase Kinase Domain >gi|119389673|pdb|2H9V|A Chain A, Structural Basis For Induced-Fit Binding Of Rho-Kinase To The Inhibitor Y27632 2F2U_A 402 1 59.3066 142 9.43455e-10 1 259 69 313 0 0 71 117 36 270 GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQ------SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRL GLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNL--MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGH-----LKLADFGTCMK-MDETGMVHC-----DTAVGTPDYIS--PEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFY---ADSLVGTYSKIMDHKNS-----LC--FPEDAEISKHAKNL G+ M ++ V K IG G FGE++L ++ + + A+KL E +K E R + + Q++ KY MV+E + G L +L + + K +++ ++ +HS LI+RDVKP+N L+ + G+ + + DF + +D H + GT Y+S + K Q R D ++G L G P+ AD+L Y KI D K + LC FPE A ++ + L 89 gi|90108644|pdb|1ZMW|A Chain A, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: T208aS212A INACTIVE DOUBLE MUTANT >gi|90108645|pdb|1ZMW|B Chain B, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: T208aS212A INACTIVE DOUBLE MUTANT 1ZMW_A 327 1 58.9214 141 9.89613e-10 8 246 15 243 0 0 64 111 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFG--------NKLDAFCGAPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+K+ + S +L E R K L + I +++ K +V+E S ++FD +K A Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 90 gi|218681962|pdb|3FE3|A Chain A, Crystal Structure Of The Kinase Mark3PAR-1: T211a-S215a Double Mutant >gi|218681963|pdb|3FE3|B Chain B, Crystal Structure Of The Kinase Mark3PAR-1: T211a-S215a Double Mutant 3FE3_A 328 1 58.9214 141 1.01241e-09 8 258 16 256 0 0 65 113 24 258 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP----QLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRR NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN-IVKLFEVIETEKTLYLIMEY--ASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-----IKIADFGFSNEF--------TVGGKLDAFCGAPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENLLKRFLVLNPIKR N+R+ K IG GNF +++L +++ T VAIK+ P +L E R K L + I +++ K +++E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN + L ++R 91 gi|90108642|pdb|1ZMV|A Chain A, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: K82r Mutant >gi|90108643|pdb|1ZMV|B Chain B, Catalytic And Ubiqutin-Associated Domains Of Mark2PAR-1: K82r Mutant 1ZMV_A 327 1 58.5362 140 1.38803e-09 8 246 15 243 0 0 62 111 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVRIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFGN--------KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+++ + S +L E R K L + I +++ K +V+E S ++FD + K Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 92 gi|110591345|pdb|2F7E|E Chain E, Pka Complexed With (S)-2-(1h-Indol-3-Yl)-1-(5-Isoquinolin-6- Yl-Pyridin-3-Yloxymethyl-Etylamine >gi|110591351|pdb|2F7X|E Chain E, Protein Kinase A Bound To (S)-2-(1h-Indol-3-Yl)-1-[5-((E)-2- Pyridin-4-Yl-Vinyl)-Pyridin-3-Yloxymethyl]-Ethylamine >gi|110591353|pdb|2F7Z|E Chain E, Protein Kinase A Bound To (R)-1-(1h-Indol-3-Ylmethyl)-2-(2- Pyridin-4-Yl-[1,7]naphtyridin-5-Yloxy)-Ehylamine >gi|145580027|pdb|2OH0|E Chain E, Crystal Structure Of Protein Kinase A In Complex With Pyridine-Pyrazolopyridine Based Inhibitors >gi|145580058|pdb|2OJF|E Chain E, Crystal Structure Of Protein Kinase A In Complex With Pyridine-Pyrazolopyridine Based Inhibitors 2F7E_E 351 1 58.151 139 1.58229e-09 13 320 48 335 0 0 80 135 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + P E +F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T +L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 93 gi|2098410|pdb|1YDT|E Chain E, Structure Of Camp-Dependent Protein Kinase, Alpha-Catalytic Subunit In Complex With H89 Protein Kinase Inhibitor N-[2- (4-Bromocinnamylamino)ethyl]-5-Isoquinoline >gi|2098412|pdb|1YDR|E Chain E, Structure Of Camp-Dependent Protein Kinase, Alpha-Catalytic Subunit In Complex With H7 Protein Kinase Inhibitor 1-(5- Isoquinolinesulfonyl)-2-Methylpiperazine >gi|2098418|pdb|1YDS|E Chain E, Structure Of Camp-Dependent Protein Kinase, Alpha-Catalytic Subunit In Complex With H8 Protein Kinase Inhibitor [n-(2- Methylamino)ethyl]-5-Isoquinolinesulfonamide 1YDT_E 350 1 58.151 139 1.71126e-09 13 238 47 258 0 0 65 99 26 232 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFP K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + ++F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P 94 gi|149243958|pdb|2UZT|A Chain A, Pka Structures Of Akt, Indazole-Pyridine Inhibitors >gi|149243962|pdb|2UZU|E Chain E, Pka Structures Of Indazole-Pyridine Series Of Akt Inhibitors >gi|149243965|pdb|2UZV|A Chain A, Pka Structures Of Indazole-Pyridine Series Of Akt Inhibitors >gi|149243968|pdb|2UZW|E Chain E, Pka Structures Of Indazole-Pyridine Series Of Akt Inhibitors 2UZT_A 336 1 58.151 139 1.71477e-09 13 238 33 244 0 0 67 101 26 232 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFP K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + P E +F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T +L GT Y++ L K ++ D ALG + G P AD + Y+KI K P 95 gi|109157919|pdb|2GNJ|A Chain A, Pka Three Fold Mutant Model Of Rho-Kinase With Y-27632 >gi|109157921|pdb|2GNL|A Chain A, Pka Threefold Mutant Model Of Rho-Kinase With Inhibitor H- 1152p 2GNJ_A 350 1 57.7658 138 2.24792e-09 13 320 47 334 0 0 81 134 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTIGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIKVADFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K IG G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + P E +F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 96 gi|281500667|pdb|2WZJ|A Chain A, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant >gi|281500668|pdb|2WZJ|B Chain B, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant >gi|281500669|pdb|2WZJ|C Chain C, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant >gi|281500670|pdb|2WZJ|D Chain D, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant >gi|281500671|pdb|2WZJ|E Chain E, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant >gi|281500672|pdb|2WZJ|F Chain F, Catalytic And Uba Domain Of Kinase Mark2(PAR-1) K82r, T208e Double Mutant 2WZJ_A 327 1 57.7658 138 2.27311e-09 8 246 15 243 0 0 63 111 24 246 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF NYRLLKTIGKGNFAKVKLARHILTGKEVAVRIIDKTQLNSSSLQKLFREVRIMKVLNHPN-IVKLFEVIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-----IKIADFGFSNEFTFG--------NKLDEFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-GKYRIPFYMSTDCENL N+R+ K IG GNF +++L +++ T + VA+++ + S +L E R K L + I +++ K +V+E S ++FD +K A Q++S ++Y H K +++RD+K EN L+ N I I DF + E+ + G+ Y + GK+ + D+ +LG + + GSLP+ G L+ER + G + + CEN 97 gi|203282506|pdb|3DXN|A Chain A, Crystal Structure Of The Calcium-Dependent Kinase From Toxoplasma Gondii, 541.M00134, Kinase Domain. 3DXN_A 287 1 57.3806 137 2.60922e-09 13 229 27 236 0 0 61 105 23 225 KKIGCGNFGELRLGKNLYTNEYVAIKL-----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFD--LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY-IDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQK KKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN-IMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLL--ESKSRDALIKIVDFGLSAHFEVGGKMKERL---------GTAYYIAPEV-LRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK KK+G G +GE+ L K+ T AIK+ S + L E KQL + I ++Y F + +V+E+ +LFD + + FS +I Q++S Y+H N+++RD+KPEN L+ +I I+DF L+ + + + K+ + GTA Y++ L K+ + D+ + G + L G P+ G + +R +K 98 gi|50513587|pdb|1SMH|A Chain A, Protein Kinase A Variant Complex With Completely Ordered N- Terminal Helix >gi|78100922|pdb|1XHA|A Chain A, Crystal Structures Of Protein Kinase B Selective Inhibitors In Complex With Protein Kinase A And Mutants 1SMH_A 350 1 57.7658 138 2.69599e-09 13 320 47 334 0 0 80 134 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEY-APGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQG-----YIQVTDFGLAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E P E +F R FS A Q++ EY+HS +LIYRD+KPEN +I + G I + DF LAK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 99 gi|2982123|pdb|1STC|E Chain E, Camp-Dependent Protein Kinase, Alpha-Catalytic Subunit In Complex With Staurosporine >gi|40889422|pdb|1Q8T|A Chain A, The Catalytic Subunit Of Camp-Dependent Protein Kinase (Pka) In Complex With Rho-Kinase Inhibitor Y-27632 >gi|40889424|pdb|1Q8U|A Chain A, The Catalytic Subunit Of Camp-Dependent Protein Kinase In Complex With Rho-Kinase Inhibitor H-1152p >gi|62737992|pdb|1SVE|A Chain A, Crystal Structure Of Protein Kinase A In Complex With Azepane Derivative 1 >gi|62737994|pdb|1SVG|A Chain A, Crystal Structure Of Protein Kinase A In Complex With Azepane Derivative 4 >gi|62738130|pdb|1VEB|A Chain A, Crystal Structure Of Protein Kinase A In Complex With Azepane Derivative 5 >gi|213424255|pdb|3E8C|A Chain A, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424256|pdb|3E8C|B Chain B, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424257|pdb|3E8C|C Chain C, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424258|pdb|3E8C|D Chain D, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424259|pdb|3E8C|E Chain E, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424260|pdb|3E8C|F Chain F, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp- Competitive Inhibitors >gi|213424278|pdb|3E8E|A Chain A, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors >gi|213424280|pdb|3E8E|B Chain B, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors >gi|213424282|pdb|3E8E|E Chain E, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors >gi|213424284|pdb|3E8E|I Chain I, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors >gi|213424286|pdb|3E8E|L Chain L, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors >gi|213424288|pdb|3E8E|P Chain P, Crystal Structures Of The Kinase Domain Of Pka In Complex With Atp-Competitive Inhibitors 1STC_E 350 1 57.3806 137 2.84703e-09 13 320 47 334 0 0 80 134 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + P E +F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 100 gi|62737996|pdb|1SVH|A Chain A, Crystal Structure Of Protein Kinase A In Complex With Azepane Derivative 8 >gi|78100912|pdb|1XH5|A Chain A, Crystal Structures Of Protein Kinase B Selective Inhibitors In Complex With Protein Kinase A And Mutants >gi|78100914|pdb|1XH6|A Chain A, Crystal Structures Of Protein Kinase B Selective Inhibitors In Complex With Protein Kinase A And Mutants >gi|78100918|pdb|1XH8|A Chain A, Crystal Structures Of Protein Kinase B Selective Inhibitors In Complex With Protein Kinase A And Mutants >gi|109157839|pdb|2GFC|A Chain A, Camp-Dependent Protein Kinase Pka Catalytic Subunit With Pki-5-24 1SVH_A 350 1 57.3806 137 2.92569e-09 13 320 47 334 0 0 80 134 38 317 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYFGPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAVQQDPALSSNREAHQHRD KTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WXLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE K +G G+FG + L K++ T + A+K+ + +E+ K++ P + K N+ MV+E + P E +F R FS A Q++ EY+HS +LIYRD+KPEN LI + G I + DF AK + T L GT Y++ L K ++ D ALG + G P AD + Y+KI K P ++ LR + ++D ++ + L+ D+ + K + DWI +++ P + P +SN + ++ + 55911 13180334 0 0 0.041 0.267 0.14